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The Operative Rib Fixation (ORiF) Study

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    ORIF Stock Image of Rib Fractures
    Why the ORIF Study

In 2016, 13,000 patients in England alone presented with chest injuries due to moderate or severe trauma. Rib fractures as a result of chest injury directly compromises breathing, commonly leading to ICU admission, pneumonia and even death. Most patients currently receive supportive care consisting of pain management, physiotherapy, assisted ventilation (if necessary) and daily multidisciplinary review. However, in recent years, there has been growing use of surgical rib fixation with plates and screws. Between 2014 and 2015, there was a 320% increase in rib fixations - despite the lack of rigorous evidence. Population data from the Trauma Audit & Research Network (TARN) suggests a marked decrease in mortality in the more severely injured, as well as quicker recovery and better health outcomes.

Management of patients with chest wall injuries represents a major financial and social burden to the NHS. Patients managed on ICUs require specialist nursing and ventilatory support and rehabilitation can be long.

The ORiF Study aims to establish if operative rib fixation, when given in addition to supportive management, reduces mortality and/or increases quality of life in patients who experience chest wall trauma. 

Collaborators

Funding

NIHR Health Technology Assessment (HTA)

Sponsorship

Nottingham University Hospitals NHS Trust 

Trial Management

Surgical Intervention Trials Unit (SITU)

Other Collaborators

SITU is part of the Oxford Clinical Trials Research Unit (OCTRU), a registered UKCRC Clinical Trials Unit based at the University of Oxford.

The Trauma & Audit Research Network (TARN)

 

Quick Links

Meet the team

Participating sites

Randomisation system (RRAMP)

 

TWEETS

 

Tweets by ORiF_Study

 

Recruitment Progress:

532
467

Date of latest recruit:

26 July, 2024

Site of latest recruit:

ORiF : Royal London Hospital
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Postal Address

The ORiF Study

Surgical Intervention Trials Unit

Botnar Research Centre

University of Oxford

Windmill Road

Oxford OX3 7LD

Email

orif@ndorms.ox.ac.uk

Telephone

+44 (0)1865 737805

+44 (0)7798 571116

IRAS ID: 248460

REC Ref: 18/SC/0666

HTA Project ID: 16/61/10

ISRCTN: 10777575